Posted on Jun 09, 2011, 6 a.m.
Variant of obesity gene may increase breast cancer risk by 30%.
New research aimed to better identify the genetic factors that lead to breast cancer has uncovered a link between the fat mass and obesity associated gene (FTO) and a higher incidence of breast cancer. Virginia Kaklamani, from Northwestern Memorial Hospital (Illinois, USA), and colleagues, have found that people who possess a variant of the FTO gene have up to a 30% greater chance of developing breast cancer. Each individual carries the FTO gene, but only 18% have this variant of the gene. Reporting that: “A significant expression of FTO [occurs] in malignant and normal breast tissue and that FTO [single nucleotide polymorphisms] in intron 1 are significantly associated with breast cancer risk,” the researchers submit that: “These FTO [single nucleotide polymorphisms] are powerful classifiers in predicting breast cancer risk.”
Kaklamani V, Yi N, Sadim M, Siziopikou K, Zhang K, Xu Y, Tofilon S, Agarwal S, Pasche B, Mantzoros C. “The role of the fat mass and obesity associated gene (FTO) in breast cancer risk.” BMC Medical Genetics 2011, 12:52, 13 April 2011.